Plant Transcription Factor Database
Previous version: v3.0
Phoenix dactylifera
HD-ZIP Family
Species TF ID Description
PDK_30s793411g008HD-ZIP family protein
PDK_30s873351g005HD-ZIP family protein
PDK_30s674671g001HD-ZIP family protein
PDK_30s733901g001HD-ZIP family protein
PDK_30s787431g001HD-ZIP family protein
PDK_30s747141g001HD-ZIP family protein
PDK_30s6550926g024HD-ZIP family protein
PDK_30s1158611g004HD-ZIP family protein
PDK_30s884401g002HD-ZIP family protein
PDK_30s768851g001HD-ZIP family protein
PDK_30s912251g001HD-ZIP family protein
PDK_30s794751g001HD-ZIP family protein
PDK_30s720261g005HD-ZIP family protein
PDK_30s682841g002HD-ZIP family protein
PDK_30s1150591g001HD-ZIP family protein
PDK_30s1100061g004HD-ZIP family protein
PDK_30s1035821g001HD-ZIP family protein
PDK_30s1014391g003HD-ZIP family protein
PDK_30s744271g001HD-ZIP family protein
PDK_30s810281g003HD-ZIP family protein
PDK_30s1133891g002HD-ZIP family protein
PDK_30s759601g003HD-ZIP family protein
PDK_30s666001g001HD-ZIP family protein
PDK_30s1100981g002HD-ZIP family protein
PDK_30s746551g001HD-ZIP family protein
PDK_30s758851g001HD-ZIP family protein
PDK_30s915541g002HD-ZIP family protein
PDK_30s707661g002HD-ZIP family protein
PDK_30s883981g003HD-ZIP family protein
PDK_30s693742g001HD-ZIP family protein
PDK_30s870691g002HD-ZIP family protein
PDK_30s1083421g001HD-ZIP family protein
PDK_30s1194391g003HD-ZIP family protein
PDK_30s929391g001HD-ZIP family protein
PDK_30s806531g001HD-ZIP family protein
PDK_30s874851g004HD-ZIP family protein
PDK_30s679881g010HD-ZIP family protein
PDK_30s979371g001HD-ZIP family protein
HD-ZIP Family Introduction

A homeobox (HB) encodes a protein domain, the homeodomain (HD), which is a conserved 60-amino acid motif present in transcription factors found in all the eukaryotic organisms. This 60-amino acid sequence folds into a characteristic three-helix structure that is able to interact specifically with DNA. Most HDs are able to bind DNA as monomers with high affinity, through interactions made by helix III (the so-called recognition helix) and a disordered N-terminal arm located beyond helix I. The high degree of conservation of this type of domain among diverse proteins from different kingdoms indicates that this structure is crucial to maintain the HD functionality and that the role played by this domain is vital.

Members of the HD-Zip family have a leucine zipper motif (LZ) immediately downstream of the HD. The two motifs are present in transcription factors found in species belonging to other eukaryotic kingdoms, but their association in a single protein is unique to plants. The HD is responsible for the specific binding to DNA, whereas LZ acts as a dimerization motif. HD-Zip proteins bind to DNA as dimers, and the absence of LZ absolutely abolishes their binding ability, which indicates that the relative orientation of the monomers, driven by this motif, is crucial for an efficient recognition of DNA.

Ariel FD, Manavella PA, Dezar CA, Chan RL.
The true story of the HD-Zip family.
Trends Plant Sci, 2007. 12(9): p. 419-26.
PMID: 17698401